HomeEndothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis? September 19, 2013 print this article Endothelial activation and apoptosis mediated by neutrophil-dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis? Barnes et al.; Ann Rheum Dis. 2011 Feb;70(2):366-72