ZNF536 antibody (pAb)

Rabbit Anti-Human/Mouse/Rat Zinc Finger Protein 536

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ZNF536 antibody (pAb)
PK-AB718-5501
  100 µg
$409.00

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ZNF536 antibody (pAb)

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ZNF536 is a recently identified zinc-finger protein that is expressed primarily in the developing nervous system and the cerebral cortex, hippocampus, and hypothalamus. ZNF536 possess ten zinc fingers and interacts with CtBP1, a corepressor for gene transcription. It is most closely related to transcriptional repressor ZNF219. Overexpression of ZNF536 in embryonic stem cells dramatically reduced the mRNA levels of neuronal marker genes such as Pax6, MAP2, and b-tubulin III following retinoic acid (RA)-induced differentiation, while depletion of ZNF536 via RNAi resulted in elevated mRNA levels of these genes, indicating its role in inhibiting neuronal cell differentiation. Overexpression of RA receptor a rescues the inhibitory role of ZNF536, suggesting that ZNF536 might inhibit RA response element-mediated transcriptional activity.

Host Species Rabbit
Host Subclass Rabbit IgG
Immunogen ZNF536 antibody was raised against a 16 amino acid peptide from near the amino terminus of human ZNF536.
Reactive Species Human, Mouse, Rat
Formulation Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/mL
Reconstitution During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Stability & Storage Antibody can be stored at 4°C for three months and at -20°C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References Mochizuki N, Shimizu S, Nagasawa T, et al. A novel gene, MEL1, mapped to 1p360.30 is highly homologous to the MDS1/EVI1 gene and is transcriptionally activated in t(1;3)(p36;q21)-positive leukemia cells. Blood 2,000; 96:3,209.