Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. It has been found to be overexpressed in human lung adenocarcinomas and squamous cell carcinomas, and the overexpression of a fragment of the 3’UTR of the ZMYM4 mRNA termed Cell Death Inhibiting RNA (CDIR) protects HeLa cells from IFN-gamma-induced apoptosis, suggesting that ZMYM4 may play a role in tumorigenesis.
|Host Subclass||Rabbit IgG|
|Immunogen||ZMYM4 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human ZMYM4.|
|Formulation||Antibody is supplied in PBS containing 0.02% sodium azide.|
|Reconstitution||During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.|
|Stability & Storage||Antibody can be stored at 4°C for three months and at -20°C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.|
|References||Saito K, Adachi N, Koyama H et al. OGFOD1, a member of the 2oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling. FEBS Lett. 2,010; 584:3,340.|