2-[(2-Methoxyethyl)thio]-3-methyl-1,4-naphthalenedione; VK3-Ome; A potent antitumor agent. Induces G2/M cell cycle arrest and apoptosis.
VK3-OCH3 is a Vitamin K3 (Menadione) analog that displays potent antitumor activity. It has been shown to induce G2/M arrest and apoptosis in neuroblastoma cells with much less cytotoxicity towards normal cells. VK3-OCH3 is believed to act through up-regulation of heme oxygenase (HO)-1.