Senescence Detection Kit II (fluorometric)

Simple, sensitive, one-step assay to measure senescence cells using FACS.

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Senescence Detection Kit II (fluorometric)
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Senescence Detection Kit II (fluorometric)

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Senescence is an arrested state in which the cells remain viable, but are not stimulated to divide by serum or passage in culture. It is thought to be a tumor-suppressive mechanism and an underlying cause of aging. Senescent cells display an increase of cell size, senescence-associated expression of β-galactosidase (SAβ-Gal) activity, and altered patterns of gene expression.

The PromoKine Senescence Detection Kits II has been designed to detect this specific senescence marker (SA-ß-Gal activity) fluorometrically in adherent and suspension cells by a simple one-step protocol using flow cytometry. The specific marker is only present in senescent cells and is not found in presenescent, quiescent, or immortal cells.