Senescence Detection Kit II (fluorometric)
Simple, sensitive, one-step assay to measure senescence cells using FACS.
Senescence is an arrested state in which the cells remain viable, but are not stimulated to divide by serum or passage in culture. It is thought to be a tumor-suppressive mechanism and an underlying cause of aging. Senescent cells display an increase of cell size, senescence-associated expression of β-galactosidase (SAβ-Gal) activity, and altered patterns of gene expression.
The PromoKine Senescence Detection Kits II has been designed to detect this specific senescence marker (SA-ß-Gal activity) fluorometrically in adherent and suspension cells by a simple one-step protocol using flow cytometry. The specific marker is only present in senescent cells and is not found in presenescent, quiescent, or immortal cells.