Senescence Detection Kit I (histochemical)
Specific detection of senescence marker in distinct pH in cultured cells and tissue sections.
Senescence is an arrested state in which the cells remain viable, but are not stimulated to divide by serum or passage in culture. It is thought to be a tumor-suppressive mechanism and an underlying cause of aging. Senescent cells display an increase of cell size, senescence-associated expression of β-galactosidase (SAβ-Gal) activity, and altered patterns of gene expression.
The PromoKine Senescence Detection Kits I has been designed to detect the specific senescence marker (SA-ß-Gal activity) histochemically in cultured cells and tissue sections. The specific marker is only present in senescent cells and is not found in presenescent, quiescent, or immortal cells.