Human Tracheal Smooth Muscle Cells (HTSMC)
Primary Human Tracheal Smooth Muscle Cells isolated from the trachea from single donors.
Primary Human Tracheal Smooth Muscle Cells (HTSMC) are isolated from the trachea from single donors and stain positive for smooth muscle α-actin. They connect the endings of the tracheal cartilage by a contractile bridge called the paries membranaceus and consequently regulate the airway lumen. Under pathological conditions like asthma, the amount of smooth muscle cells in the trachea walls is increased leading to smooth muscle hypertrophy or hyperplasia. Hence, HTSMC are suitable for in vitro studies of asthma and other pulmonary diseases.
- Cryopreserved: Cryogenic vial containing 500.000 viable cells.
- Proliferating: >500.000 viable cells shipped in growth medium (T25 flask).
- Cell pellet: 1 million cells dissolved in 200µl RNAlater© for subsequent RNA, DNA or protein analysis. Cell pellets cannot be revived.
|Recommended Plating Density||7.500 – 10.000 cells per cm2|
|Passage After Thawing||P2|
|Tested Markers||Smooth muscle α-Actin positive|
|Guaranteed Population Doubling||> 15|
|Guaranteed Population Doublings||> 15|
Technical Library (1)
What is the precise localization for HBSMC and HTSMC?
Bronchial (HBSMC) and tracheal smooth muscle cells (HTSMC) are isolated from the smooth muscle layer of trachea (trachealis muscle) and bronchi, respectively.
Related Links and Documents
- What is the precise localization for HBSMC and HTSMC?
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Reference Literature (3)
Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes
Dreymueller et al.; J Immunol. 2014 Jan 15;192(2):722-31
Innate immune receptors in human airway smooth muscle cells: activation by TLR1/2, TLR3, TLR4, TLR7 and NOD1 agonists
Mansson Kvarnhammar et al.; PLoS One. 2013 Jul 4;8(7):e68701
Hyaluronic acid influence on platelet-induced airway smooth muscle cell proliferation
Swensson Holm et al.; Exp Cell Res. 2012 Mar 10;318(5):632-40
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