Human Pulmonary Artery Smooth Muscle Cells (HPASMC)
Primary Human Pulmonary Artery Smooth Muscle Cells isolated from human pulmonary arteries.
Primary Human Pulmonary Artery Smooth Muscle Cells (HPASMC) are isolated from human pulmonary arteries and stain positive for smooth muscle α-actin. They are suited for studying the function of pulmonary arteries under normal and disease conditions (e.g. vasoconstriction induced by alveolar hypoxia). They are also useful for physiological studies of vascular smooth muscle cells.
- Cryopreserved: Cryogenic vial containing 500.000 viable cells.
- Proliferating: >500.000 viable cells shipped in growth medium (T25 flask).
- Cell pellet: 1 million cells dissolved in 200µl RNAlater© for subsequent RNA, DNA or protein analysis. Cell pellets cannot be revived.
|Recommended Plating Density||7.500 – 10.000 cells per cm2|
|Passage After Thawing||P2|
|Tested Markers||Smooth muscle α-Actin positive|
|Guaranteed Population Doubling||> 15|
|Guaranteed Population Doublings||> 15|
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Reference Literature (23)
Vesicle miR-195 derived from endothelial cells inhibits expression of serotonin transporter in vessel smooth muscle cells
Gu et al.; Sci Rep. 2017 Mar 8;7:43546
MURC deficiency in smooth muscle attenuates pulmonary hypertension
Nakanishi et al.; Nat Commun. 2016 Aug 22;7:12417
Proteomic analysis of vascular smooth muscle cells in physiological condition and in pulmonary arterial hypertension: toward contractile versus synthetic phenotypes
Regent et al.; Proteomics. 2016 Oct;16(20):2637-2649
Exogenous H2O2 induces growth inhibition and cell death of human pulmonary artery smooth muscle cells via glutathione depletion
Park; Mol Med Rep. 2016 Jul;14(1):936-42
Affinity-tuned ErbB2 or EGFR chimeric antigen receptor T cells exhibit an increased therapeutic index against tumors in mice
Liu et al.; Cancer Res. 2015 Sep 1;75(17):3596-607
The zinc transporter ZIP12 regulates the pulmonary vascular response to chronic hypoxia
Zhao et al.; Nature. 2015 Aug 20;524(7565):356-60
Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension
Wojciak-Stothard et al.; Circulation. 2014 Apr 29;129(17):1770-80
Treatment with anti-gremlin 1 antibody ameliorates chronic hypoxia/SU5416-induced pulmonary arterial hypertension in mice
Ciuclan et al.; Am J Pathol. 2013 Nov;183(5):1461-73
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis
Chun et al.; J Clin Invest. 2008 Oct;118(10):3343-54
Effects and mechanism of oridonin on pulmonary hypertension induced by chronic hypoxia-hypercapnia in rats
Wang et al.; Chin Med J (Engl). 2009 Jun 20;122(12):1380-7
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