Human Coronary Artery Smooth Muscle Cells (HCASMC)
Human Coronary Artery Smooth Muscle Cells isolated from the human coronary arteries.
Primary Human Coronary Artery Smooth Muscle Cells (HCASMC) are isolated from human coronary arteries and stain positive for smooth muscle α-actin. Coronary arteries supply the heart with blood and obstruction in atherosclerosis causes myocardial infarction.
HCASMC are qualified to study the function of smooth muscle cells in the development of atherosclerotic plaques or in other diseases like hypertension. They are also useful for stent-graft compatibility testing.
- Cryopreserved: Cryogenic vial containing 500.000 viable cells.
- Proliferating: >500.000 viable cells shipped in growth medium (T25 flask).
- Cell pellet: 1 million cells dissolved in 200µl RNAlater© for subsequent RNA, DNA or protein analysis. Cell pellets cannot be revived.
|Recommended Plating Density||7.500 – 10.000 cells per cm2|
|Passage After Thawing||P2|
|Tested Markers||Smooth muscle α-Actin positive|
|Guaranteed Population Doubling||> 15|
|Guaranteed Population Doublings||> 15|
Technical Library (1)
We are culturing human coronary artery smooth muscle cells (HCASMC) from your company. Are these cells obtained from large arteries like LAD or left Circumflex or from small branches of LAD etc. ?
Our HCASMC (C-12221) are isolated from the large arteries, i.e. from
- Right coronary artery
- Left main coronary artery
- Circumflex coronary artery and
- Left anterior descending coronary artery.
Related Links and Documents
- We are culturing human coronary artery smooth muscle cells (HCASMC) from your company. Are these cells obtained from large arteries like LAD or left Circumflex or from small branches of LAD etc. ?
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Reference Literature (49)
Cardioprotective effects of Cu(II)ATSM in human vascular smooth muscle cells and cardiomyocytes mediated by Nrf2 and DJ-1
Srivastava at.; Sci Rep. 2016 Dec 21;6(1):7
Vesicle miR-195 derived from endothelial cells inhibits expression of serotonin transporter in vessel smooth muscle cells
Gu et al.; Sci Rep. 2017 Mar 8;7:43546
Tailored surface design of biodegradable endovascular implants by functionalization of poly (L-lactide) with elastin-like proteins
Petersen et al.; Journal of Biomedical Engineering and Informatics. 2016;2(1)
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Miller et al.; Nat Commun. 2016 Jul 8;7:12092
Secreted matrix metalloproteinase-9 of proliferating smooth muscle cells as a trigger for drug release from stent surface polymers in coronary arteries
Gliesche et al.; Mol Pharm. 2016 Jul 5;13(7):2290-300
Pimecrolimus increases the expression of interferon-inducible genes that modulate human coronary artery cells proliferation
Hussner et al.; Eur J Pharmacol. 2016 Aug 5;784:137-46
Targeting in-stent-stenosis with RGD- and CXCL1-coated mini-stents in mice
Simsekyilmaz et al.; PLoS One. 2016 May 18;11(5):e0155829
Sortilin mediates vascular calcification via its recruitment into extracellular vesicles
Goettsch et al.; J Clin Invest. 2016 Apr 1;126(4):1323-36
Expression of OATP2B1 as determinant of drug effects in the microcompartment of the coronary artery
Hussner et al.; Vascul Pharmacol. 2015 Sep;72:25-34
LMNA mutations resulting in lipodystrophy and HIV protease inhibitors trigger vascular smooth muscle cell senescence and calcification: Role of ZMPSTE24 downregulation
Afonso et al.; Atherosclerosis. 2016 Feb;245:200-11
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