Human Cardiac Microvascular Endothelial Cells (HCMEC)

Primary Human Cardiac Microvascular Endothelial Cells isolated from heart ventricles from a single donor.

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Primary Human Cardiac Microvascular Endothelial Cells (HCMEC) are isolated from heart ventricles from a single donor. The cells are routinely analyzed by immunofluorescent staining: they stain positive for CD31 and Willebrand factor and negative for smooth muscle alpha-actin.

HCMEC intensively interact with cardiomyocytes and therefore have a characteristic phenotype different from other microvascular endothelial cells. HCMEC play an important role in the physiological regulation of coronary blood flow and capillary exchange. Medical conditions such as hypertrophy, ischemia, hypertension, and diabetes mellitus are associated with endothelial dysfunction.

Recommended Plating Density 10.000 – 20.000 cells per cm2
Passage After Thawing P2
Tested Markers von Willebrand Factor (vWF) positive, CD31 positive, Dil-Ac-LDL uptake positive
Guaranteed Population Doublings > 10

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