Human Bronchial Smooth Muscle Cells (HBSMC)
Human Bronchial Smooth Muscle Cells isolated from the human bronchi from single donors.
Primary Human Bronchial Smooth Muscle Cells (HBSMC) are isolated from the bronchi from single donors and stain positive for smooth muscle α-actin. They connect the endings of the bronchial cartilage and consequently regulate the airway lumen. Under pathological conditions like asthma, the amount of smooth muscle cells in the bronchi walls is increased leading to smooth muscle hypertrophy or hyperplasia. Hence, HBSMC are suitable for in vitro studies of asthma and other pulmonary diseases.
|Recommended Plating Density||7500 – 10000 cells per cm2|
|Passage After Thawing||P2|
|Tested Markers||Smooth muscle α-Actin positive|
|Guaranteed Population Doublings||> 15|
Technical Library (1)
What is the precise localization for HBSMC and HTSMC?
Bronchial (HBSMC) and tracheal smooth muscle cells (HTSMC) are isolated from the smooth muscle layer of trachea (trachealis muscle) and bronchi, respectively.
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- What is the precise localization for HBSMC and HTSMC?
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Reference Literature (7)
The TLR7 agonist imiquimod induces bronchodilation via a non-neuronal TLR7-independent mechanism: a possible role for quinoline in airway dilation
Larsson et al.; Am J Physiol Lung Cell Mol Physiol. 2016 Jun 1;310(11):L1121-9
Inhibition of 12-lipoxygenase reduces platelet activation and prevents their mitogenic function
Svensson Holm et al.; Platelets. 2014;25(2):111-7
Hyaluronic acid influence on platelet-induced airway smooth muscle cell proliferation
Swensson Holm et al.; Exp Cell Res. 2012 Mar 10;318(5):632-40
Aged red garlic extract reduces cigarette smoke extract-induced cell death in human bronchial smooth muscle cells by increasing intracellular glutathione levels
Jeong et al.; Phytother Res. 2012 Jan;26(1):18-25
Cigarette smoke and α,β-unsaturated aldehydes elicit VEGF release through the p38 MAPK pathway in human airway smooth muscle cells and lung fibroblasts
Volpi et al.; Br J Pharmacol. 2011 Jun;163(3):649-61
Functional and biochemical rationales for the 24-hour-long duration of action of olodaterol
Casarosa et al.; J Pharmacol Exp Ther. 2011 Jun;337(3):600-9
Differential regulation of neurotrophin expression in human bronchial smooth muscle cells
Kemi et al.; Respir Res. 2006 Jan 29;7:18
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