Acinus (IN) antibody (pAb)

Rabbit Anti-Human Acinus (Inducer of Chromatin Condensation)

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Acinus (IN) antibody (pAb)
PK-AB718-2219
  100 µg
$409.00

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Acinus (IN) antibody (pAb)

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Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS’.

Host Species Rabbit
Host Subclass Rabbit IgG
Immunogen Rabbit polyclonal Acinus antibody was raised against a peptide (DTSENRPENDVPEPP) corresponding to amino acids 775 to 789 of human AcinusL, 48 to 62 of human AcinusS’, or 17 to 31 of human AcinusS, which differ from those of mouse Acinus by one amino acid
Reactive Species Human
Formulation Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Stability & Storage Antibody can be stored at 4°C for three months and at -20°C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References Zamzami N, Kroemer G. Condensed matter in cell death. Nature 1,999 ;401:127.