ACE2 (CT) antibody (pAb)

Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor)

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ACE2 (CT) antibody (pAb)
PK-AB718-3217
  100 µg
$409.00

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ACE2 (CT) antibody (pAb)

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Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Host Species Rabbit
Host Subclass Rabbit IgG
Immunogen Rabbit polyclonal ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2 (Genbank accession NP_068576).
Reactive Species Human
Formulation Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/mL
Reconstitution During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Stability & Storage Antibody can be stored at 4°C for three months and at -20°C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References Donoghue M, Hsieh F, Baronas E, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotension I to angiotension 1. Circ. Res. 2,000;87:1_x005FTipnis SR, Hooper NM, Hyde R, et al. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol. Chem. 2,000;275:33,238_x005FLi W, Moore MJ, Vasileva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2,003;426:450.