ACE1 Inhibitor Screening Kit

Simple fluorometric assay that can be used to identify and characterize Angiotensin I Converting Enzyme inhibitors/activators in a high-throughput format.

ACE1 Inhibitor Screening Kit
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ACE1 Inhibitor Screening Kit

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PromoCell’s ACE1 Inhibitor Screening Kit can be used to screen for potent inhibitors of ACE1 activity to regulate hypertension. It utilizes the ability of an active ACE1 to cleave a synthetic o-aminobenzoyl peptide (Abz-based peptide substrate to release a free fluorophore). The released Abz can be easily quantified using a fluorescence microplate reader. In the presence of an ACE1 specific inhibitor, the enzyme loses its peptidase activity which results in decrease of fluorescence intensity. This assay kit is simple and can be used to identify and characterize ACE1 inhibitors in a high-throughput format.