ABCA7 antibody (pAb)

Rabbit Anti-Human ATP-binding Cassette Sub-family A ABC1 member 7 (ABC1, CERP)

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ABCA7 antibody (pAb)
PK-AB718-6889
  100 µg
$409.00

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ABCA7 antibody (pAb)

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ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.

Host Species Rabbit
Host Subclass Rabbit IgG
Immunogen ABCA7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ABCA7.
Reactive Species Human
Formulation Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/mL
Reconstitution During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Stability & Storage Antibody can be stored at 4°C for three months and at -20°C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References Tefferi A, Levine RL, Lim KH, et al. Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIPL1-PDGFRA correlates. Leukemia 2,009; 23:900_x005FSchaub FX, Looser R, Li S, et al. Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms. Blood 2,011; 115:2,003.