AATF / Che-1 antibody (pAb)

Rabbit Anti-Human/Mouse Rabbit Anti-Apoptotic Transcription Factor

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AATF / Che-1 antibody (pAb)
PK-AB718-3039
  100 µg
$409,00

AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the b-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer’s disease (AD), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.

Host Species Rabbit
Host Subclass Rabbit IgG
Immunogen Rabbit polyclonal AATF antibody was raised against a 12 amino acid peptide from near the carboxy terminus of human AATF (Genbank accession No. NP_036270).
Reactive Species Human, Mouse
Formulation Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/mL
Reconstitution During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 μl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Stability & Storage Antibody can be stored at 4°C for three months and at -20°C for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
References Kawai T, Matsumoto M, Takeda K, et al. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. Mol. Cell Biol. 1,998; 18:1,642.Lindfors K, Halttunen T, Huotari P, et al. Identification of novel transcription factor-like gene from human intestinal cells. Biochem. Biophys. Res. Commun. 2,000; 276:660.Xie J and Guo Q. AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. Neurobiol. of Dis. 2,004; 16:150.Xie J and Guo Q. AATF inhibits aberrant production of amyloid beta peptide 1 by interacting directly with Par-4. J. Biol. Chem. 2,004; 279:4,596.(WD1105)