Drug/Metabolite Transporter Assays

P-glycoprotein (P-gp, Multidrug Resistance Protein 1, MDR1) is an ABC transporter that strongly affects the oral absorption, tissue distribution and excretion of many drugs. Overexpression of P-gp makes tumor cells resistant to a range of chemically and pharmacologically distinct chemotherapeutic drugs.

PromoCell’s MDR1/P-gp Ligand Screening Kit is designed for rapidly screening test compounds for modulating efflux transporter activity in MDR1-expressing cells. This highly sensitive, fluorometric assay has a simple no-wash protocol
and is adaptable for high throughput.