Study and fight Coronavirus with research tools from PromoCell

The rapidly spreading Coronavirus Disease – known as COVID-19 – is not only threatening peoples’ health and lives but also worldwide mobility and the economy. To support the efforts of researchers worldwide to study, understand and combat this new health threat, PromoCell offers a range of high-quality antibodies specifically directed against components of the SARS-CoV-2 and the ACE2 receptor.

COVID-19 is caused by a novel Coronavirus (CoV) called SARS-CoV-2, also known as 2019-nCoV. The disease outbreak was first discovered in Wuhan, China but has spread to many other countries with up-to-date millions of laboratory-confirmed infections and several hundred thousand of fatal cases. The World Health Organization (WHO) has declared a global health emergency to gather resources and remedy this threat.

Background

There are four coronavirus genera: alpha-coronavirus, beta-coronavirus, gamma-coronavirus, and delta-coronavirus. SARS-CoV-2 belongs to the beta-coronavirus genus originating from bats. Beta-coronaviruses can infect mammals, are zoonotic pathogens, and can cause severe respiratory disease in humans.

Other viruses in this family are SARS coronavirus (SARS-CoV) and MERS coronavirus. SARS-CoV-2 has approximately 79% sequence identity to SARS-CoV and 50% to MERS-CoV which gives us clues as to how it may infect and cause disease in humans. In addition, homology modeling shows SARS-CoV-2 has a similar receptor-binding domain structure as SARS-CoV which suggests SARS-CoV-2 uses the angiotensin-converting enzyme-2 (ACE2) receptor in humans for infection. A significant amount of research has already been done to understand ACE2 and how it may be used as a host receptor by viruses, giving us a head-start when fighting COVID-19.

The ACE2 SARS-CoV-2 Interaction

ACE2 is expressed in the human heart, lung, kidney and gastrointestinal tract and is an essential regulator of heart function and blood pressure. ACE2 is a functional receptor, acting as the entry point into human lung cells for both SARS-CoV and the human respiratory coronavirus (HCoV-NL63). This makes it a potential target for therapy that could prevent COVID-19 infection.
Research into the interaction between SARS-CoV-2 and ACE2 is key as this dynamic is crucial to understanding both cross-species and human to human transmissions of COVID-19.

Tools to Study COVID-19

SARS-CoV-2-Receptor

To support the efforts of researchers worldwide to study, understand and combat this new health threat, PromoCell offers a range of high-quality antibodies specifically directed against components of the SARS-CoV-2 and the ACE2 receptor.

As ACE2 is a potential therapeutic target not only for cardiovascular disorders but also for coronavirus-induced diseases, we also provide an ACE2 Activity Assay as well as an ACE Inhibitor Screening Assay to further support research progress in this field.

Please note: All products are for research use only and not for in vitro-diagnostic or therapeutic purposes.

Product list

SARS Antibodies & Blocking Peptides

PK-AB718-3219 SARS Spike (NT) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3219P SARS Spike (NT) peptide Viral SARS Spike (NT) Antibody Blocking Peptide 50 µg
PK-AB718-3221 SARS Spike (IN1) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3221P SARS Spike (IN1) peptide Viral SARS Spike (IN1) Antibody Blocking Peptide 50 µg
PK-AB718-3223 SARS Spike (IN2) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3223P SARS Spike (IN2) peptide Viral SARS Spike (IN2) Antibody Blocking Peptide 50 µg
PK-AB718-3225 SARS Spike (IN3) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3225P SARS Spike (IN3) peptide Viral SARS Spike (IN3) Antibody Blocking Peptide 50 µg
PK-AB718-3525 SARS Spike (CT) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3525P SARS Spike (CT) peptide Viral SARS Spike (CT) Antibody Blocking Peptide 50 µg
PK-AB718-3527 SARS M (NT) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3527P SARS M (NT) peptide Viral SARS M (NT) Antibody Blocking Peptide 50 µg
PK-AB718-3529 SARS M (CT) antibody (pAb) Rabbit Anti-SARS Virus Membrane Protein 100 µg
PK-AB718-3529P SARS M (CT) peptide Viral SARS M (CT) Antibody Blocking Peptide 50 µg
PK-AB718-3531 SARS E (NT) antibody (pAb) Rabbit Anti-SARS Virus Envelope Protein 100 µg
PK-AB718-3531P SARS E (NT) peptide Viral SARS E (NT) Antibody Blocking Peptide 50 µg
PK-AB718-3533 SARS E (CT) antibody (pAb) Rabbit Anti-SARS Virus Envelope Protein 100 µg
PK-AB718-3533P SARS E (CT) peptide Viral SARS E (CT) Antibody Blocking Peptide 50 µg

ACE2 Antibodies & Blocking Peptides

PK-AB718-3215 ACE2 (IN1) antibody (pAb) Rabbit Anti-Human/Mouse Angiotensin Converting Enzyme 2 (SARS Receptor) 100 µg
PK-AB718-3215P ACE2 (IN1) peptide Human ACE2 (IN1) Antibody Blocking Peptide 50 µg
PK-AB718-3217 ACE2 (CT) antibody (pAb) Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) 100 µg
PK-AB718-3217P ACE2 (CT) peptide Human ACE2 (CT) Antibody Blocking Peptide 50 µg
PK-AB718-3227 ACE2 (NT) antibody (pAb) Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) 100 µg
PK-AB718-3227P ACE2 (NT) peptide Human ACE2 (NT) Antibody Blocking Peptide 50 µg
PK-AB718-3229 ACE2 (IN2) antibody (pAb) Rabbit Anti-Human Angiotensin Converting Enzyme 2 (SARS Receptor) 100 µg
PK-AB718-3229P ACE2 (IN2) peptide Human ACE2 (IN2) Antibody Blocking Peptide 50 µg

Assays

PK-CA577-K897 ACE2 Activity Assay Kit Fast, and simple fluorometric detection of Angiotensin II Converting Enzyme activity in tissue/cell lysates. 100 assays
PK-CA577-K310 ACE2 Inhibitor Screening Kit Simple fluorometric assay that can be used to identify and characterize Angiotensin II Converting Enzyme inhibitors/activators in a high-throughput format. 100 assays

Related Products

Moreover, we supply a huge variety of Cytokines & Growth Factors as well as the corresponding ELISAs & Antibodies for Immunology/Innate Immunity (e.g. to detect cytokine storm and acute inflammation).

In addition, PromoCell provides a wide range of assays to study Cell Health & Viability , Oxidative Stress, Cell Metabolism & Signaling and Cell Migration & Phagocytosis.

Please visit also our page summarizing our respiratory cell culture tools for COVID-19 research.

Please note: All products are for research use only and not for in vitro-diagnostic or therapeutic purposes.

Promotion

Use the promotion code PK-AB-1/20 when purchasing on our webshop one of the above listed products:
- SARS Antibodies and Blocking Peptides
- ACE2 Antibodies and Blocking Peptides
- ACE Assay Kits

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