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Keratinocytes

Primary Normal Human Epidermal Keratinocytes (NHEK) are available from single or from pooled donors isolated from the epidermis of juvenile foreskin or adult skin from different locations like the face, the breasts, the abdomen, and the thighs. They are the major cell type in the epidermis, making up about 90% of the cells.  
(Normal Human Dermal Fibroblasts (NHDF) and Normal Human Epidermal Melanocytes (NHEM) cultured in M2 medium from the same donor are available on request.)

Epidermal keratinocytes originate in the stratum basale and move up through the layers of the epidermis. During this movement, they undergo gradual differentiation and morphology changes until they reach the stratum corneum, where they form a layer of nucleus-free, flat, and highly keratinized squamous cells. This layer forms an effective barrier to the entry of infectious agents into the body and minimizes moisture loss.

Keratinocytes are also able to produce a variety of cytokines, growth factors, interleukins and complement factors. Therefore keratinocytes are important for wound healing, inflammation, and immune response.

Figure: Structure of the epidermis.

Recommended media & reagents

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References, Questions & Answers

Product Name Size Catalog Number Information Prices
Normal Human Epidermal Keratinocytes (NHEK) juvenile foreskin, single donor 500,000 cryopreserved cells C-12001 click to select country
Normal Human Epidermal Keratinocytes (NHEK) juvenile foreskin, single donor 500,000 proliferating cells C-12002 click to select country
NHEK.f single donor Pellet 1x106 cells in RNAlater C-14001 click to select country
Normal Human Epidermal Keratinocytes (NHEK) juvenile foreskin, pooled 500,000 cryopreserved cells C-12005 click to select country
Normal Human Epidermal Keratinocytes (NHEK) juvenile foreskin, pooled 500,000 proliferating cells C-12007 click to select country
NHEK.f pooled Pellet 1x106 cells in RNAlater C-14003 click to select country
Normal Human Epidermal Keratinocytes (NHEK) adult, single donor 500,000 cryopreserved cells C-12003 click to select country
Normal Human Epidermal Keratinocytes (NHEK) adult, single donor 500,000 proliferating cells C-12004 click to select country
NHEK adult, single donor Pellet 1x106 cells in RNAlater C-14002 click to select country
Normal Human Epidermal Keratinocytes (NHEK) adult, pooled 500,000 cryopreserved cells C-12006 click to select country
Normal Human Epidermal Keratinocytes (NHEK) adult, pooled 500,000 proliferating cells C-12008 click to select country
NHEK adult, pooled Pellet 1x106 cells in RNAlater C-14004 click to select country