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Human Dermal Lymphatic Endothelial Cells (HDLEC)

Primary Human Dermal Lymphatic Endothelial Cells (HDLEC) are a subpopulation of the Human Dermal Endothelial Cells. They are isolated from the dermis of juvenile foreskin and adult skin (different locations) from a single donor.
(Human Dermal Blood Endothelial Cells (HDBEC) from the same donor are available on request.)

The cells are routinely analyzed by flow cytometric analysis and immunofluorescent staining:
> 95% of the cells are CD31 positive
  and podoplanin positive. In addition, the cells stain positive for Prox-1.

Lymphatic vessels transport excess fluids from tissues to the circulatory system and are a major component of the immune system. The transported fluid is nearly cell free. The vessels are highly permeable, because they lack a continuous basal membrane. Lymphatic endothelial cells are involved in pathological alterations of the lymphatic system. During tumor lymphangiogenesis, the lymphatic endothelial cells build new vessels that infiltrate tumors, attract tumor cells, and induce tumor cell metastasis. 

Figure 1: Flow cytometric analysis of PromoCell HDLEC. 99% of the cells are CD31 positive.

Figure 2: Flow cytometric analysis of PromoCell HDLEC. 96% of the cells are Podoplanin positive.

Recommended media & reagents

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References, Questions & Answers

Product Name Size Catalog Number Information Prices
Human Dermal Lymphatic Endothelial Cells (HDLEC) juvenile foreskin 500,000 cryopreserved cells C-12216 click to select country
Human Dermal Lymphatic Endothelial Cells (HDLEC) juvenile foreskin 500,000 proliferating cells C-12218 click to select country
HDLEC Pellet 1x106 cells in RNAlater C-14020 click to select country
Human Dermal Lymphatic Endothelial Cells (HDLEC) adult donor 500,000 cryopreserved cells C-12217 click to select country
Human Dermal Lymphatic Endothelial Cells (HDLEC) adult donor 500,000 proliferating cells C-12219 click to select country
HDLEC adult Pellet 1x106 cells in RNAlater C-14021 click to select country