Applications
- Angiogenesis research
- Oncology
- Drug uptake studies
- Cell-cell junction investigation
- Inflammation studies
Features
- Von Willebrand factor (vWF) positive
- CD31 positive
- Smooth muscle alpha-actin negative
- Cryopreserved at second passage
Human Dermal Blood Endothelial Cells (HDBEC)
HDBEC are a subpopulation of the Human Dermal Endothelial Cells. They are isolated from the dermis of juvenile foreskin and adult skin (different locations) from a single donor. (Human Dermal Lymphatic Endothelial Cells (HDLEC) from the same donor are available on request.)
The cells are routinely analyzed by flow cytometric analysis and immunofluorescent staining: they are > 95% CD31 positive and stain positive for von Willebrand factor. In addition, they are > 90% negative for podoplanin and stain negative for smooth muscle specific alpha-actin.
Blood Endothelial Cells have a key function in physiological processes like vessel tonus, capillary permeability, blood coagulation, fibrolysis, and angiogenesis. They are also useful for disease studies of atherosclerosis, tumor genesis, and thrombosis.
Figure 1: Flow cytometric analysis of PromoCell HDBEC. 98% of the cells are CD31 positive.
Figure 2: Flow cytometric analysis of PromoCell HDBEC. 91% of the cells are Podoplanin negative.
Recommended media & reagents
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Knowledge Base
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